机械工业职业卫生状况研究

对１２２４个工种（岗位）的工人接触生产性毒物、粉尘、高温的状况以及部分工种（岗位）的工人体力劳动强度状况进行了调研，初步了解到机械工业的主要职业危害因素、危害分布、危害程度和特征。     

五氯酚对环境污染及居民健康影响研究

中国长期以来使用五氯酚纳盐杀灭亡血吸虫的中间宿主──—钉螺．为评价它对环境的污染及居民健康危害，１９９０－１９９３年在我省开展了五氯酚环境污染及对居民健康影响研究．在研究区采集环境样品（空气、水体、土壤及底泥、蔬菜、肉、蛋、鱼等）共１７３份；生物材料（人血、尿）共４５７份，分析五氯酚浓度．结果在明，在五氯酚使用区，环境中ＰＣＰ浓度稍高于对照区，而生物材料尿、血中ＰＣＰ浓度明显高于对照区．全血胆碱脂酶活性用药区明显低于对照区，统计学分析有显著差异（Ｐ＜０．００１），证实了长期低剂量使用可造成环境及生物蓄积．     

土壤侵蚀信息系统的结构设计

本文介绍了黄土地区土壤侵蚀信息系统的建造原理与方法。分析探讨了土壤侵蚀各因子计算机自动提取的算法，以及土壤侵蚀预测模型的构造方法，并用灰色控制系统的原理确定了模型的参数。并以山西省离石县王家沟流域羊道沟为例进行了试验研究。     

地面水中叶枯灵的高效液相色谱测定

本文采用反相高效液相色谱法，在质控条件下，对河水，塘水两种地面水中叶枯灵的检验方法进行了测试，用Shimapck ODS柱为分析柱，以甲醇：水＝50：50为流动相，并用冰醋酸调PH至4－5，紫外检测波长281nm，两种水样的平均回收率分别为91．7－96．3％，90－95．8％，相对标准偏差为4．3％，最低检出限为0．0261mg/l，为地面水中叶枯灵卫生标准的实施提供了简便，灵敏，正确的配套测试手段。     

陕南化龙山珍稀濒危植物的保护和利用

化龙山是大巴山系在川陕境内的最高山峰,海拔２９１７．２ｍ,植物资源丰富,有野生维管植物１９７７种,隶属１８６科８１５属。化龙山是陕西省珍稀濒危植物资源最丰富的地区,共有国家保护的珍稀濒危植物２２科３０属３３种,其中属一级保护１种,二级保护１１种,三级保护２１种,属濒危２种,稀有１４各,渐危１７种,珍稀濒危植物古老成分较多,并以第三纪孑遗成分为主单少型属和中国特有属分别是１６属和１０属。这些珍稀濒危     

The role of condensed organic matter in the nonlinear sorption of hydrophobic organic contaminants by a peat and sediments

This study examines the effect of soil organic matter heterogeneity on equilibrium sorption and desorption of phenanthrene, naphthalene, 1,3,5-trichlorobenzene (1,3,5-TCB), and 1,2-dichlorobenzene (1,2-DCB) by soils and sediments. Two estuary sediments, a Pahokee peat (PP; Euic, hyperthermic Lithic Haplosaprist), and two subsamples (base- and acid-treated peat [TP] and acid-treated peat [FP]) of the peat were used as the sorbents. The contents of black carbon particles were quantified with a chemical extraction method. Petrographical examinations revealed the presence of the condensed soil and sediment organic matter (SOM) in Pahokee peat. The Freundlich isotherm model in two different forms was used to fit both sorption and desorption data. The results show that the sorption and desorption isotherms are generally nonlinear and that the apparent sorption-desorption hysteresis is present for phenanthrene and TCB. Detailed analysis of sorption data for the tested sorbent-sorbate systems indicates that black carbon is probably responsible for sorption isotherm nonlinearity for the two sediments, whereas the humic substances and kerogen may play the dominant role in nonlinear sorption by the peat. This investigation suggests that the microporosity of SOM is important for the hydrophobic organic contaminant (HOC) sorption capacity on the peat.     

西部大开发要加强生态环境保护和建设

在实施西部大开发进程中,对原本生态环境十分脆弱的现状必须予以重视,切实加强生态环境保护与建设。     

流动注射分光光度法测定水中铝的含量

以桑色素作显色剂，采用流动注射分光光度法测定水中铝的含量。在桑色素质量浓度为0．8g／L、聚氧乙烯辛基苯基醚体积分数为1．0％、进样环体积为400μL、检测波长420nm的条件下，采用流动注射分光光度法对水中铝的含量进行测定，本方法的线性范围为2～300μg／L，检出限（信噪比为3）为0．124μg／L，相对标准偏差为2．9％，加标回收率为96．4％～101．8％。     

The fungicide difenoconazole alters mRNA expression levels of human CYP3A4 in HepG2 cells

The fungicide difenoconazole has been frequently detected in agricultural products, soils and surface waters, causing increasingly public concern due to toxicological properties. Although systemic triazole fungicides can inhibit the enzymatic activity of many CYP450 isozymes, how difenoconazole affects the human CYP3A4 still remains largely unknown. We thus investigated the effect of difenoconazole on normal mRNA expression and protein expression of human CYP3A4 by real-time quantitative PCR and western blot, respectively. Results show that the exposure to difenoconazole from 0.01 to 0.5 μM for 24 h down-regulates mRNA expression levels of human CYP3A4 in HepG2 cells. We also found that difenoconazole could inhibit the enzymatic activity of human CYP3A4 in a concentration-dependent mode. The IC₅₀ of difenoconazole for inhibition of CYP3A4 activity is 0.41 µM, showing a stronger inhibitor in comparison with ketoconazole. Overall, our findings indicate the potential risk of difenoconazole for the disruption of human CYP3A4.